Reyes is known for his fusion of many of the world's percussion techniques, including the ability to play a drum set with his hands in addition to the traditional use of drumsticks; it was said that he can "sound like a drummer and a percussionist at the same time"[1][2][3] He was a member of Santana and joined Chicago as the percussionist from 2012 to 2018, at which point he took over the drum seat.

His native name of Walfredo de los Reyes Palau IV is a traditional Cuban combination of his paternal and maternal surnames.

He is a third generation musician in a prolific professional musical lineage on both sides of his family, including several globally recognized percussion experts.

[8][9] Leading up to his current role with the band Chicago, Reyes had a connection as a lifelong fan of the band, as a long-time friend of and collaborator with former drummer Tris Imboden,[10]: 47  and as brother of Chicago's previous percussionist Daniel de los Reyes.

[11] For the 2021 movie Being the Ricardos, Reyes coached and mentored Javier Bardem in learning the conga drums performed in the film.