The incoming Saxons called the earlier native inhabitants (the Celtic Britons) Walas or Wealas, meaning "foreigner".

Walton Manor later passed through the Breres and Atherton families until it was sold in 1804 to Liverpool banker Thomas Leyland.

[8] Moulded plastics company Dunlop had its UK head office and manufacturing plant on what is now the Cavendish Retail Park (off Rice Lane and opposite the former Walton Hospital) until the mid-1990s.

In September 1980, a severe fire at the plant closed Rice Lane and residents were told to stay indoors due to hazardous atmospheric pollution.

The building used as the main headquarters was left abandoned for many years until a Chinese restaurant was opened in the late 1990s on the site.

[citation needed] On August 3, 2024, Walton was affected by the 2024 United Kingdom riots: 300 people gathered near County Road Mosque and the Spellow Lane Library Hub and a local shop were set on fire.

The gardens closed in the early 1900s and the only surviving remains is the Ticket Booth, which is now a pizza takeaway beside The Plough function rooms (formerly a public house).

Rice Lane City Farm is also in Walton, at the end of Rawcliffe Road, occupying the land that once was Liverpool Parochial Cemetery.

The former Shell garage on Rice Lane (now a used car dealership) was once the official workshop of Ferrari for their race team when competing at Aintree Grand Prix course in the 1950s.

They had previously played at Anfield Stadium on the opposite side of Stanley Park, which then became the home of Liverpool Football Club.

The Liverpool Walton constituency was long a bastion of the left in the Labour Party with a Marxist influence stretching back to the 1950s.

Walton on the Hill railway station was by the Queens Drive flyover, on the Rice Lane side heading southbound.