She was the fourth actress to portray Santana Andrade in the NBC soap opera Santa Barbara from 1991 to 1992.

In 1994 she returned to the big screen, starring in the crime drama The Glass Shield, and appeared alongside Jimmy Smits in Death and the Maiden at the Mark Taper Forum.

In 2002, De Jesus starred opposite Clint Eastwood in the mystery thriller film Blood Work playing Graciella Rivers, a Latino woman still enraged over the murder of her sister.

[1] From 2002 to 2003 she had a recurring role on the CBS crime series CSI: Miami as MDPD Detective Adelle Sevilla.

[7][1] In 2010, De Jesus had a recurring role as Iris Blanco, the mayor of Pine Valley in the ABC soap opera, All My Children.