As an actor, he is best known for his roles in television series Love Actually (2017), Gank Your Heart (2019), The Untamed (2019), Legend of Fei (2020), Luoyang (2021), Being a Hero (2022) and Man of Faith (2024).

[4] In 2023, Wang Yibo made his big screen lead role debut with movies Hidden Blade, Born to Fly and One and Only.

During his second year in secondary school in 2011, Wang participated in IBD national dance competition and placed in the top sixteen in the hip-hop category, he then became a trainee of Yuehua Entertainment.

[citation needed] Wang debuted in 2014 as a member of South Korean-Chinese boy band group Uniq with the song "Falling in Love".

[8] He then played the role of Red Boy in A Chinese Odyssey Part Three,[9] and starred in the romance comedy drama series Love Actually as the second male lead character Zhai Zhiwei.

[21] In one of the show's episodes, Wang revealed that he had a disease called myocarditis during his childhood and had to give up dancing and undergo serious medication to recover.

[22] In 2019, Wang starred in the esports romance drama series Gank Your Heart, playing a misunderstood professional gamer.

The song, composed by 24 and Vince from The Black Label with Wang participated in the lyrics writing, expresses his determination to follow his own path and find his self-worth.

[50][51] In June 2021, Wang played the role of Jiang Xianyun, a Chinese historical figure, in the episode The Choice (抉择) of the movie series Faith Makes Great (理想照耀中国).

[52] In the same month, Wang was chosen as one of the nine individuals appearing in Youku's serial documentary My Legacy and I Season 2, which follows the life and work of nine Chinese outstanding performers in their fields over the past two and half years.

[53] Wang played an anti-narcotics policeman in the crime drama series Being a Hero directed by Fu Dongyu, headlining alongside Chen Xiao.

[54] He also starred as Baili Hongyi in the period mystery drama series Luoyang alongside Huang Xuan and Victoria Song.

Wang's first film in a leading role, Hidden Blade, a neo-noir spy thriller set mostly in Shanghai during the Japanese occupation, was released in China on 22 January 2023.

The film tells the story of a team of special elite pilots in the Chinese air force (PLAAF), who were tasked with testing out new fighter jets.

[60] In July, One and Only, a comedy starring Wang as a young break-dancer who dreams and struggles to enter a professional team and compete for the Asian Game trophy, was released.

[65] On 29 July, WildAid ambassador Wang Yibo's journey in search of the Chinese pangolin, the documentary series Defenders of the Hidden premiered on Youku.

[68] Partnering with over 30 brands,[69] his endorsement ranges from domestic products such as Master Kong[70] and Pechoin[71] to international ones like Lacoste,[72] Evisu[73] and Shu Uemura.

[82] In March 2021, Wang terminated his contract with the company after Nike criticized China for human rights violations against Uyghurs in Xinjiang, in the aftermath of U.S. sanctions on cotton grown in the region that followed widespread allegations of forced labor.

[92] Wang has appeared on the front covers of the Chinese edition of various international magazines, such as Elle, GQ, Marie Claire, Cosmopolitan and Harper's Bazaar.

[94] Wang has used his image to raise awareness for multiple causes, such as Firefighting Public Welfare of Luoyang City,[95] SOS Children's Villages' campaign with Qingsongchou "No Child Alone: I want to have a family",[96] the Civil Traffic of Hunan Province,[97] and "Earth Aid, Green Life on the Table", a campaign co-sponsored by WildAid, China Green Carbon Foundation, and Food and Agriculture Organization.

In January 2020, Wang and more than 200 celebrities donated a total of 278 million yuan to Han Hong Charity Foundation in order to help the city of Wuhan, an area vastly affected.

[101] Wang also sang a number of original songs as a tribute to front liners of the COVID-19 pandemic and to convey love and hope during those challenging times.

[102] In March 2020, Wang and Xinhua News Agency launched the tribute song "We Stay Together" (因为我们在一起) to inspire people to work together against the pandemic.

[105][106] In the same month of the year, Wang received numerous unsolicited phone calls from callers who purchased his personal telephone number online.