Short and stout in physical stature, with a kindly visage, Wapello entertained friendly relations with white settlers throughout his life.
In 1829, he led his tribe to Muscatine Slough on the west bank of the Mississippi River and later settled in Iowa.
During this trip, Wapello made an eloquent speech at Boston, Massachusetts, wherein he expressed friendly sentiments towards white settlers and reaffirmed his desire to continue harmonious relations with them.
While on a hunting trip near the Skunk River east of Ottumwa, Iowa, Wapello died on March 15, 1842.
He was later buried in accordance with his oft-expressed wish that he be laid to rest alongside his good friend General Street, at the site of the government agency in what is now a small park named Chief Wapello's Memorial Park located southeast of Agency, Iowa.