Wapi Pathum (Thai: วาปีปทุม, pronounced [wāː.pīː pā.tʰūm]; Northeastern Thai: วาปีปทุม, pronounced [wa᷇ː.pīː pā.tʰu᷇m]) is a district (amphoe) of Maha Sarakham province, northeastern Thailand.

Neighbouring districts are (from the south clockwise): Na Dun, Na Chueak, Borabue, Mueang Maha Sarakham, and Kae Dam of Maha Sarakham Province; Si Somdet, Chaturaphak Phiman, Kaset Wisai, and Pathum Rat of Roi Et province.

The district is divided into 15 sub-districts (tambons), which are further subdivided into 240 villages (mubans).

Nong Saeng is a sub-district municipality (thesaban tambon) which covers parts of tambon Nong Saeng.

There are a further 15 tambon administrative organizations (TAO).