The second season of the American television series Warehouse 13 premiered on July 6, 2010, and concluded on December 7, 2010, on Syfy.

The show stars Eddie McClintock, Joanne Kelly, Saul Rubinek, Genelle Williams and Allison Scagliotti.

Pete and Myka find that Artie has survived the explosion thanks to the Phoenix artifact, which was slipped into his pocket by MacPherson during their struggle.

Meanwhile, Leena keeps having vertigo, and it is revealed that her condition is due to residual energy from MacPherson trapped in her brain, which Mrs. Frederic and The Regents removed.

Wells returns and starts helping them collect artifacts and is reinstated as an agent, which annoys Artie since he doesn't trust her.

After Sheldon (Sean Maher), a Detroiter, finds an artifact that seemingly grants him superpowers, he begins a vigilante crusade to stop the crime that is threatening the city and Loretta (Jewel Staite), the woman he loves.

Pete and Myka go undercover in the fashion industry to find an artifact causing models to age years in a few seconds.

Artie helps Claudia with her misgivings about going on a date with Todd (Nolan Gerard Funk), a guy working in the local hardware store.

In this crossover with Eureka, Dr. Douglas Fargo (Neil Grayston) is enlisted to upgrade the Warehouse's computer system.

Pete and Myka have to locate the man who designed the security system, Hugo Miller (René Auberjonois), and bring him back to the Warehouse to save the day.

Pete has a secret assignment and runs into former flame Kate Logan (Tia Carrere), which may result in him betraying the team.

When it becomes clear that Wells has her hands on the original weapon of mass destruction, Artie, Claudia, and Mrs. Frederic race against the clock to stop her deadly endgame.

While Pete and Myka go to Los Angeles to investigate a timely Christmas-related artifact, Claudia searches for the perfect gift for Artie.