The highway continues through the towns of Roma and Mitchell in the Maranoa Region of South West Queensland.

The Warrego Highway's lowest point along its length is 3.69 m just east of where it crosses the Bremer River near Ipswich, and its highest elevation is at the top of the Great Dividing Range on the Toowoomba Bypass.

Warrego Highway (A2) was rerouted via the bypass between Helidon Spa (in the east) and the interchange at Charlton (in the west).

[9] These projects began in 2017 to fully duplicate the highway to 4 lanes, between Cecil Plains Road and Black Street.

A project to upgrade priority sections of the Toowoomba to Ipswich corridor, including the Warrego Highway and surrounding state and council roads, at an estimated cost of $75 million, was in planning in May 2020.

[23] A project to upgrade the Brimblecombe Road intersection between Toowoomba and Dalby, at a cost of $2,75 million, was completed in December 2021.

[27] A project to plan the upgrade of the Mount Crosby Road intersection, at a cost of $5 million, was in progress in July 2021.