Teachers at Warren Central include Katelyn Blaha, Donna Forsythe, Lauren Tanner, Nann Harwood, Keshia Cagle, and Nathan Dick.

[2] Former teachers include Virgil Livers who played football for the Chicago Bears, Douglas Jenkins who was the first recipient of the President's Award For Excellence in Math and Science Teaching,[3] Dr. Tracy Inman who is an author and associate director of The Center for Gifted Studies at WKU,[4] and Ruth Lanphear, author.

Warren Central High School participates in the following Kentucky High School Athletic Association (KHSAA) sanctioned varsity athletics: basketball, baseball, cross country, football, golf, soccer, softball, tennis, track and field, and volleyball.

They advanced to the final four of the Sweet 16 for the third time in four years in 2007, falling to Louisville Ballard in the state semifinals.

In 2010 Warren Central returned to the Sweet 16 for the first time since their six-year run ended in 2007, where they advanced to the quarterfinals.

Jeremy Anderson, a 2007 alumni, played in the Sweet 16 five-consecutive years, only the 2nd player in Kentucky to accomplish this.

But after a great season they eventually lost in the 1st round to Madisonville North Hopkins with a final score of 12–39.

Some of these organizations include local chapters of national organizations such as National Beta Club, Fellowship of Christian Athletes (FCA), Future Business Leaders of America (FBLA), and Family, Career, and Community Leaders of America.