He was a railway porter, maintenance fitter and welder, real estate agent, farmer, grazier, crocodile catcher and company director before entering politics.
"[7] On 10 November 2009, Entsch announced that he would again run for pre-selection for the seat of Leichhardt[8] and was re-elected to parliament at the August 2010 election defeating the man who had succeeded him in 2007, Labor incumbent Jim Turnour.
[21] In local matters, Entsch has proposed the sale of housing commission properties to tenants, the same mechanism by which his own parents had become home owners.
[22] Enstch has become a supporter of a spaceport on the Cape York Peninsula proposed by Space Centre Australia, where “I started as a sceptic and I’m now an absolute disciple.
In February of 2016 he was one of the politicians who succeeded in passing a reform bill approved for conditions ranging from chronic pain to anxiety and depression.
He also criticised prominent Yes campaigner Noel Pearson, who he called a "crony" and rejected his large influence in local politics on the Cape York Peninsula.
In his December 2019 report to environment minister Sussan Ley he stated "Global climate change looms as the most serious existential threat to the long-term health and viability of the Reef.
[35] On 17 August 2015, against Abbott's wishes, Entsch introduced a private member's bill to legalise same-sex marriage, arguing it would prevent Australia from being "a divided nation.