He has held the positions of Minister of Social Development and Human Security, Minister of Industry, Minister of Commerce and Deputy Minister of Commerce in the government of Thailand.

Watana Muangsook's nickname is Kai.

He graduated from Suankularb Wittayalai School and Chulalongkorn University.

He was also a temple boy at Wat Debsirindrawas Ratchaworawiharn.

He is married to a daughter of billionaire Sumet Jiaravanon, Patchara Jiaravanon.