She had previously participated in the ODM-Kenya primaries, which she claimed were rigged in favor of incumbent legislator Peter Kyalo Kaindi, forcing her to switch to Chama Cha Uzalendo.

Although the document was unpopular in the Machakos District, the majority of Kenyans voted in favour of the new constitution, which President Mwai Kibaki promulgated on 27 August 2010.

In 2017, Ndeti and Makueni governor Kivutha Kibwana pledged to rejoin Wiper Democratic Movement under a brokered agreement known as the Emali Declaration.

Ndeti ditched Chama Cha Uzalendo for Wiper on the morning of 5 April 2017, in line with the law that requires candidates to change political parties within 90 days of an election.

[6] This led to the WDM-K NEB awarding a direct nomination to former Machakos County Secretary for Education Jackson Kala[7] to represent the party in the Senate election.

Ndeti was appointed as chief administrative secretary for the State Department for Public Works and also State Department for Shipping and Maritime in the Ministry of Transport, Infrastructure, Housing, Urban Development and Public Works on Tuesday, 14 January 2020 by President Uhuru Kenyatta following a reshuffle and new appointments of chief administrative secretaries.

She was a Wiper Democratic Movement -Kenya candidate for Machakos governor in 2017 where she garnered over 209,000 votes in a disputed poll which saw the incumbents election initially overturned at the Court of Appeal.