The Super NES and Sega Mega Drive/Genesis games were developed by Gray Matter and feature only Wayne as a playable character.

The NES version keeps true to the plot of the original film, as the premise involves Wayne and Garth trying to stop a rich producer from buying their public access television show.

[2] The first level takes place at Kramer's Music Store, where Wayne fights several sentient instruments to obtain the Excallbur,[3] such as guitars, drums, cymbals, saxophone, trumpets, and stacks of Barry Manilow records.

[4] In the second level, Wayne and Garth go to the Gasworks to battle bouncers, martial artists, and tough guys[5] in order to meet Cassandra, who is performing with her band at the venue.

[11] The player controls both characters, each with different attacks; Wayne uses karate kicks learned by his girlfriend Cassandra, and Garth is equipped with a 4000-volt laser gun.

[25] Jonathan Davies of Super Play, reviewing the SNES version, was bored with it, describing its gameplay as only "jumping around collecting things" with the only appealing factors being its voice samples and Wayne and Garth's faces.

[36] Commenting on the NES version, GamePro's Data Carvey praised the game's humor, such as with its enemies, between-level cutscenes, and manual, but panned its perceived lack of difficulty and poor presentation; he wrote that the enemies were easily beatable, the backgrounds and sprites were "undetailed" and "flat," and its audio consisted of a "pretty cheesy soundtrack" and sparse sound effects reminiscent of games from the 1980s.