Wayne L. Hubbell (born 24 March 1943) is an American biochemist and member of the National Academy of Sciences.
His research focuses on the visual system, and is primarily supported by a grant from the National Eye Institute.
Dr. Hubbell's laboratory developed site-directed spin labeling (SDSL), a technique for the exploration of protein structure and dynamics.
By changing the genetic code, a specific attachment point in the protein is created for a nitroxide spin label probe.
Analysis of the electron paramagnetic resonance (EPR) spectrum of the spin label provides information about the local environment in the protein.