West of Target Field station the Wayzata Sub sees about 4-6 trains a day, consisting of manifest, grain, and ethanol traffic.

The Wayzata Sub also occasionally sees other commodities such as coal and oil trains, and can sometimes receive intermodal or Amtrak reroutes when needed.

Some Great Northern passenger trains ran along this line, though service was cut back to just the Empire Builder upon the formation of Amtrak in 1971.

Service to the Minneapolis Great Northern Depot stopped in the late 1978, when trains were shifted to Midway station in Saint Paul.

The Empire Builder changed to its modern routing along the Staples Subdivision in late 1979 when the North Coast Hiawatha ended service.