[1] The first two school years were held in the basement of Sequoyah Hills Presbyterian Church.

[1] At the time, the Sequoyah Hills location was considered "West Knoxville," and the new campus was beyond the outskirts of the city.

[4] In early 2007, Webb's Honor the Tradition, Realize the Vision campaign to renovate and expand the campus began.

Phase I included building the new Jim and Kay Clayton Science Center, which was finished in October 2007.

Also starting in fall of 2019 in the Upper School Learning Commons, meant to serve the same purpose as the Innovation Center, but with added features such as a cafe and possibly virtual reality.

The final project beginning that fall is the new Central Building, meant to be a newer entrance to Webb's campus.

[14] Sports include: baseball, basketball, bowling, cheerleading, climbing, cross country, diving, field hockey, football, golf, lacrosse, sailing, soccer, softball, swimming, tennis, track and field, volleyball, and wrestling.

The Spartans hold an intense rivalry with Knoxville Catholic High School that dates back to the 1970s.

[citation needed] The Spartans' first state football title (TSSAA Class A) was in the fall of 1981, when the team fielded fewer than 20 players in any one game, and most starters played offense and defense.

They went 7-3 in the regular season (losing to only one Class A team) and then beat Sweetwater, Coalfield, and Meigs County in the playoffs.

In 2005, the Webb Spartans were finalists in TSSAA Division II-AA, losing 0-26 to the Evangelical Christian School.

The next season, the Spartans were moved to Division II-AA and made the playoffs, but lost in the first round to Montgomery Bell Academy.

Webb brought home its sixth state championship in 2012 when the Spartans defeated ECS, 47-14.