It is the sequel to Klane's 1989 comedy Weekend at Bernie's and starring Andrew McCarthy, Jonathan Silverman, Terry Kiser, and Barry Bostwick.

It tells the story of Larry and Richard once again ending up with their late boss' corpse which is targeted by a voodoo queen hired by mobsters who want to find the $2,000,000.00 that Bernie embezzled.

Meanwhile in the U.S. Virgin Islands, a voodoo queen named Mobu is hired by mobsters to find the $2 million Bernie stole.

She sends two servants Henry and Charles to go to New York, get Bernie's body, use a voodoo ceremony to reanimate him, and bring him back to her so he can lead her to the money.

After their release, they find Bernie, whom they believe is still completely dead, stuff him into a suitcase, bring him with them to the Virgin Islands, and put him into a small refrigerator in their hotel room.

With one of the mobsters holding a gun to his head, she forces Richard to drink a poisonous potion and tells them they must find the map by sundown to get the antidote.

Larry tries to scoop up the money, but is caught by Hummel (now slightly unhinged upon seeing the undead Bernie walk) and he gives the $2 million to him.

With Mobu out of commission, Claudia's father, a medical doctor, says that he can cure Richard if he can get the blood of a virgin (which Larry confesses he can provide).

The website's consensus reads, "It would appear to be all but impossible to make a worthwhile sequel to a comedy about a corpse's exploits—odds Weekend at Bernie's II never comes close to beating.

[15] Similar to Beavis and Butt-Head, Rick and Morty would also parody the premise of the Bernie's series in their episode "Rixty Minutes" wherein in an alternate universe, Jerry Smith is revealed to have written and directed a film entitled Last Will and Testimeow: Weekend at Dead Cat Lady's House II about a group of cats attempting to act as their elderly owner after she dies in her sleep.

This includes dating, making out with, and ultimately engaging in sexual intercourse with their owner's estate holder despite the body visibly fighting to keep from decomposition, to the point one cat has to open the mouth, which is not only rotting, but is seen to have maggots inside.

[16] On The Eric Andre Show, specifically the Season 5 episode "The ASAP Ferg Show", the titular host, Andre, "reenacted" the Bernie's series by walking around with someone dressed as, and acting dead like, Bernie, going up to random people and letting them know (despite a majority of people not having any interest), even specifically mentioning the sequel by name.

[18] Even professional athletes began performing the dance, including Baltimore Ravens running back Ray Rice after scoring a touchdown during a nationally-televised January 2011 game against the Pittsburgh Steelers.

[19] The 2012 Oakland Athletics adapted "Movin' Like Bernie" into their celebration routines after Coco Crisp played the song for third baseman Brandon Inge in the team's clubhouse before a game.