[1] Although the title and format change took effect with issue 13, Gaines and Feldstein decided not to restart the numbering in order to save money on second class postage.

Artist/writer Harry Harrison claims credit for originally turning Gaines on to the idea of publishing science fiction.

[3] Harrison had no editorial control over the contents of the comic aside from his own stories, and he left EC by the end of 1950.

Artists who drew stories for this EC title were Feldstein, Frazetta, Williamson, Orlando, Wally Wood, Harvey Kurtzman, George Roussos, Harrison, Reed Crandall, Will Elder, Bernard Krigstein, Jack Kamen, John Severin and Mac Elkin.

Writers in the early issues included Feldstein, Gaines, Kurtzman, Harrison and Gardner Fox.

[4] Creators Gaines and Feldstein made cameos in the stories "Cosmic Ray Bomb Explosion" (14, July–August 1950), "7 Year Old Genius" (7) and "The Expert" (14) and "The Ad" (14).

"Judgment Day" featured an astronaut who comes to a planet populated by orange and blue robots who hope to join the Galactic Republic.

This story was chosen for reprinting approximately three years later in Incredible Science Fiction, which resulted in an argument that caused Gaines to quit comics altogether.

Specific story influences that have been identified include the following: After their publication of "Home to Stay", Ray Bradbury contacted EC about their plagiarism of his work.