Weird Science is an American television sitcom, based on John Hughes' 1985 film of the same title, that aired on the USA Network from March 5, 1994, to April 11, 1997.

The series follows the adventures of Gary Wallace (John Mallory Asher) and Wyatt Donnelly (Michael Manasseri), two socially inept high-school students in a fictional suburb of Chicago.

However, a freak lightning storm brings her to life, creating Lisa (Vanessa Angel), a gorgeous genius with the powers of a "magic genie".

[2] In the pilot episode, Gary claims that creating Lisa is possible because he "saw it in a John Hughes movie", referring to the original Weird Science film.

Kari Lizer, one of the staff writers, who later went on to create The New Adventures of Old Christine, said, "Weird Science turned out to be the best job because it made me realize I was more than an actress who could write monologues for herself.