Alice Klieg, a mentally ill single woman living on disability benefits and fan of Oprah Winfrey, wins the California Stack Sweepstakes lottery jackpot of $86 million.

She appears on the local TV news celebrating her win but is upset when the speech she prepared is abruptly cut off after she mentions using masturbation as a sedative.

During a vitamin supplement infomercial presented by Gabe Ruskin, Alice, who is in the studio audience, responds to his request for a volunteer, hijacks the broadcast, and tries to recite her speech once again (although is again cut off by the director).

During the first episode, Alice announces she has given up her medication and includes a silent five-minute segment of herself eating meatloaf cake with mashed sweet potato icing and a live re-enactment of a scene from her past (with actors wearing name-cards playing her and a friend who had betrayed her in high school).

Rainer Ybarra, a graduate student and fan of the show, interviews Alice about her rising stardom, and the two go on a date which ends with her fellating him in her limousine.

She invites her family and Gina to the broadcast - a lavish telethon aimed at finding owners for her dogs which she has neutered along with making amends to everyone she has wronged.

In the show's last moments, Alice gives a heartfelt apology to Gina, praises her for her patience, and presents her with a check for the remaining $7 million of her lottery winnings.

On March 20, 2013, Kristen Wiig was in talks to join the cast of the film and re-team with Anchorman 2: The Legend Continues cohorts Will Ferrell and Adam McKay, who produced.

The site's critical consensus reads, "A transfixing central performance by Kristen Wiig holds Welcome to Me together and compensates for its uneven stretches.

Scott wrote that "By turns touching, amusing and genuinely disturbing, [Welcome To Me] defies expectations and easy categorization, forgoing obvious laughs and cheap emotional payoffs in favor of something much odder and more interesting.