The album's lead single "We Used to Be Friends" was the theme song to the popular TV series Veronica Mars as well as its subsequent film adaptation.

[4] The musical style of Welcome to the Monkey House was described by XRay Magazine as a "belligerent, snotty-nosed, speed-fueled romp through sinister electro punk, slightly corrupt melodic rock and skew-whiff handle of 80s glam-sodden pop, albeit refracted through a knowing noughties thrift store cool.

AllMusic wrote, "With their fifth album [...] the band capitalizes on their pop sensibilities and even manages to turn their prior weaknesses into strengths, resulting in a collection of gloriously blank, cleverly stupid neo-new wave songs.

[13] A negative review came from Pitchfork, which gave the album a low 3.3/10 rating and wrote "these songs highlight the poseur mentality and insincerity that paradoxically plagues and blesses The Dandy Warhols".

The enhanced CD contains the short film The End of the Old as We Know It, written and directed by Courtney Taylor-Taylor, and a link to The Odditorium, a no-longer-active website where fans could "see band web casts, play games and download exclusive music and mayhem".