[3] Only the Wells Fargo Plaza offers direct access from the street to the Houston tunnel system (a series of underground walkways connecting many of downtown Houston's office towers); otherwise, entry points are from street-level stairs, escalators, and elevators located inside buildings that are connected to the tunnel.

[4] Wells Fargo Plaza features a wide variety of fine amenities for its tenants including The Houstonian Lite Health Club located on the 14th floor.

Sky lobbies on the 34/35th and 58/59th floors are publicly accessible and offer views of Downtown Houston.

In 1993, the Consulate-General of the United Kingdom in Houston leased 9,707 square feet (901.8 m2) in the First Interstate Plaza.

The company moved over 700 jobs from a suburban office building along U.S. Route 290 (Northwest Freeway) to the Wells Fargo Plaza.

[11] In 2006, Targa Resources signed an 11-year lease to occupy 101,600 square feet (9,440 m2) of space in the Wells Fargo Plaza.

[23][24] Greenberg Trauig (one of the top ten largest law firms in the USA) is also a tenant of Wells Fargo Plaza.