The magazine's regular columnists include the former president of the Social Democratic Party of Switzerland, Peter Bodenmann, as well as Christoph Mörgeli MP, a leading figure of the right wing Swiss People's Party, and cultural and social commentator Alexander, Count von Schönburg-Glauchau.

The magazine's editorial stance under Köppel is considered to range between economic liberalism and conservatism – regularly along the lines of the Swiss People's Party, as critics allege.

Weltwoche remained a fixture of the intellectual environment in Switzerland, publishing articles, columns and interviews on a wide range of topics, including politics, the economy, culture and science, generally from a center-left perspective.

The last editor in chief before the takeover by Köppel was Fredy Gsteiger (1997 to 2001), under whom the newspaper pursued a general political position of center-left liberalism.

For instance, virtually alone among Swiss publications, Die Weltwoche in 2003 and 2004 printed lengthy articles mainly arguing for the 2003 invasion of Iraq or the reelection of George W. Bush to the U.S. presidency.

The accession of Switzerland to the European Union is rejected by the editorial staff, as was Swiss acceptance of the Schengen Agreement.

[8][9] In keeping with its neo-conservative and anti-mainstream positions, the Weltwoche does not accept the scientific evidence for global warming and has denounced recent "alarmism" surrounding environmental issues.

On 12 January 2006, Die Weltwoche was the first German-speaking publication to reprint some of the controversial cartoons of Muhammad originally published by the Danish newspaper Jyllands-Posten.