Since 1363, Wenceslaus II began his studies in the University of Prague, and in the decade of 1370 he travelled to Montpellier, France, where he obtained a degree in canon law.

On 3 December 1375, Wenceslaus II was appointed by Pope Gregory XI as Bishop of Lebus, although by canon law, the legal minimum age for this type of post was thirty years.

In 1378, the chance to obtain the diocese of Breslau appeared before Wenceslaus II , because the bishop elect, Theodore of Klatow, didn't receive papal approval.

Wenceslaus II quickly became known for his forceful politics, standing invariably at the side of the Roman Papacy; as a reward for his loyalty in 1385, Pope Urban VI wanted to give him the title of cardinal.

In the first years of his rule in the Breslau Diocese, Wenceslaus II was merged in a bitter dispute with the local nobility, who tried to eliminate the law immunities of the Church.

The settlement was finally made in 1382: Breslau obtained the right to import goods from outside the clergy district (permitted only on the acquisition of their own needs, without the possibility of sales).

In the disputes between the Silesian Duchies and the Church, he didn't hesitate to use the excommunication on his relatives (for example, the ban was applied by him to Duke Bolko IV of Opole).

This attitude caused several problems for Wenceslaus II, in particular the attacks on estates whose leaders were banned by him (like Duke Henry IX of Lüben).