Although he was the eldest son and had strong potential to inherit his father's duchy, Konrad IV decided to pursue a religious vocation.

During this time, Konrad IV devoted himself to his candidacy for the bishopric of Warmia, undertaking a long journey to Rome in pursuit of this appointment.

During his tenure as ruler of the Diocese of Wrocław and the Duchy of Nysa-Otmuchów, Konrad IV faced the challenges of the Hussite Wars, a period of significant political upheaval that greatly influenced the duke-bishop's policies.

In recognition of his contributions, the Emperor appointed Konrad IV to Governor of Silesia with the official responsibility of organizing the fight against the Hussites in 1422.

In January 1423, Konrad IV participated in negotiations for a possible alliance between Emperor Sigismund and the Teutonic Order against King Władysław II of Poland.

To counter the Hussite threat, the Silesian princes and several major cities, including Wrocław and Świdnica, sought mutual aid from Konrad IV and offered him leadership of the coalition.

After the battle, Prokop's army devastated large parts of Lower and Upper Silesia, particularly targeting the possessions of the Bishopric of Wrocław.

In search of protection, Konrad IV forged a closer alliance with Duke Bolko V of Opole, one of the most prominent Hussite leaders among the Silesian princes.

In the following years, despite the defeat of 1428, Konrad IV continued to wage war against the Hussites in Silesia, receiving support from the majority of the Wroclaw nobility.

As a result, Konrad IV lost two important fortresses, Niemcza and Otmuchów, which he regained five years later by buying them from Hussite commanders.

In 1433, in order to protect the property of the Church, Konrad IV decided to revive the Union of Silesian Princes (Związek książąt śląskich) and once again assumed the position of its leader.

Konrad IV's extensive involvement in political affairs and prolonged wars had a significant impact on the bishopric, resulting in a substantial debt of 8,500 Hungarian guilders at the time of his death.

This prompted the chapter to investigate the matter, which revealed that Konrad IV had amassed considerable sums of money from both Western and Orthodox churches within the diocese.

As a result, on 1 August 1444, the chapter formally decided to depose Konrad IV, citing his substantial personal debts and lack of funds to maintain his court.