Wendell Lim is an American biochemist who is the Byer's Distinguished Professor of Cellular and Molecular Pharmacology at the University of California, San Francisco.
[8][9][10][11] He helped pioneer the use of optogenetic response modules as a way to exert control of intracellular signaling and its use in profiling how cells respond to temporal patterns of stimulation.
[12][13][14] He has also worked on identifying common regulatory network modules that perform fundamental cellular functions such as amplification, adaptation, spatial self-organization, polarized cell movement, and temporal sensing.
[25] In addition, Lim's group has used these synthetic receptors to design positive feedback circuits for sensing antigen density with non-linear thresholds.
[28] Lim was part of the team that invented the CRISPRi system that used modular DNA targeting of inactive Cas9 to control the transcription of specific endogenous genes.
[31] His group has also participated in the synthetic biology outreach program iGEM with San Francisco Bay Area high school students and teachers.