[4] Macpherson won her first pro title at age 18 in the 1986 U.S. Women's Open, while she was still a high school senior.
On July 2, 2006, she became the first female bowler to win a USBC Open Championships title when she fired an 812 series (248-300-264) in the singles competition; it was nine days after the death of her father.
In December 2008, Macpherson was elected to the USBC Hall of Fame for Superior Performance; she was inducted with the 2009 class.
Making the field of 16 for the Bayer Earl Anthony Medford Classic as an alternate in January 2009, she eventually won the title over previous Women's Series champion Stefanie Nation, 199-184.
[8] Macpherson started competing in the Japan Professional Bowling Association (JPBA) in 2004, winning the 2004 JLBC Prince Cup in her first appearance.