Wenonah is located in the southeast portion of Minneapolis, as part of a greater community of 11 neighborhoods called Nokomis.

[5] Its boundaries are defined by 54th Street East to the north, 34th Avenue South to the east, the Minneapolis-Saint Paul International Airport to the south, and Cedar Avenue to the west.

[5] For the most part, the neighborhood lies to the north of Minnesota State Highway 62 with the exception of a vestigial 33-property area surrounded on three sides by the Airport and only connected to the greater neighborhood by 28th Avenue South,[5] which runs below Highway 62.

[5] Wenonah borders three other neighborhoods directly, including Diamond Lake to the west, Keewaydin to the north, and Morris Park to the east, and touches corners with Minnehaha to the northeast.

[8] Wenonah is located in Ward 11,[9] currently represented by city council member Emily Koski.