Her father is an author and professor of social sciences and her mother is veteran Nigerian broadcaster and television host Ruth Benamaisia-Opia.

[4] After making her television debut with a guest appearance in a 2010 episode of The Bill, Opia spent a year with the Renegade Theatre Company in Nigeria.

[6] Opia gained prominence through her role as Cleopatra Ofoedo in the third series of the BBC comedy Bad Education and its 2015 spinoff film.

[7] Opia was nominated in 2015 in the Nollywood Actress of the Year category at the 2015 Nigeria Entertainment Awards for her role in the film When Love Happens.

Opia starred as Terry Pratchard in Michaela Coel's BBC series I May Destroy You, which first aired in June 2020.