She is best known for her role as Linda McCray in the Netflix miniseries When They See Us, for which she was nominated for the Primetime Emmy Award for Outstanding Supporting Actress in a Limited Series or Movie.

[4] Blake has played many roles on Broadway and Off-Broadway productions, including The Merchant of Venice, Come and Gone, The Crucible, An Octoroon, and Hurt Village.

In 2015, Blake joined the cast of the Netflix comedy-drama series Orange Is the New Black playing Berdie Rogers.

[5] Along with the cast, she received the Screen Actors Guild Award for Outstanding Performance by an Ensemble in a Comedy Series.

In 2019, Blake played Linda McCray in the Netflix miniseries When They See Us directed by Ava DuVernay.