[4] The school is named after John Wesley, the founder of Methodism, and all faculty are professed Christians from varying denominations.

Wesleyan School was established in 1963 as a part of Sandy Springs United Methodist Church.

During her tenure, Wesleyan became an independent, Christian, college preparatory school, offering curriculum for kindergarten through 12th grade.

In the winter of 1996, the board hired Zach Young, former Vice President and Assistant Headmaster at The Westminster Schools, to replace the retiring Adler.

That year, the facilities consisted of 15 modular units, a soccer field, and the school's first permanent structure, Marchman Gymnasium.

This new property adjoins the campus along Peachtree Parkway and is used for physical education, soccer, football, cross country, and lacrosse.

The building contains classrooms, a theater, a dining hall, a library, a prayer chapel, science and computer labs, and office space.

Wesleyan School christened Gillfillan Hall administrative offices and announced the completion of the current Spalding Drive campus master plan at a ceremony on September 24, 2007.

Gillfillan is adjacent to Marchman Gymnasium and houses the offices of the Head of School, Development, Business, Communications and Admissions in its 12,000 square feet (1,100 m2).

In the middle school, the students are divided by gender in math and English classes to accommodate for purported learning differences between boys and girls.

[5] The high school offers AP classes in Capstone Research, Capstone Seminar, Computer Science, English Language, English Literature, French Language and Culture, Spanish Language and Culture, Calculus AB, Calculus BC, Statistics, Biology, Chemistry, Environmental Science, Physics, European History, Macroeconomics, Microeconomics, United States Government and Politics, United States History, Music Theory, and Studio Art.

According to U.S. News & World Report, 70% of students from the class of 2011 matriculated at colleges and universities ranked in the top 100 schools.

High school offers 2D, 3D, and Digital Art, Photography, Symphonic Band, Class Piano, and Chorus.

Wesleyan's volleyball team, under Coach Ted Russell, won state championships in 2004, 2005, 2006, 2007, 2009, and 2013.

The boys' cross-country team, under the leadership of Brian Kennerly (1998–2009) and Chad McDaniel (2010–present), won state championships in 2001, 2002, 2005, 2006, 2007, 2009, 2010, 2011, 2014, 2018, 2019, and 2020.

The girls' cross-country team, under the leadership of Libby Houk (1999–2001), Dan Byrne (2002–2008) and Chad McDaniel (2011–present), won state championships in 2001, 2002, 2003, 2012, 2013, 2020, 2021, 2022, 2023, and 2024.

In 2008, Sports Illustrated named Wesleyan the top school in athletics in Georgia,[7] and sixteenth in the nation.