It flows southwest for some distance before turning nearly due south and passing under Pennsylvania Route 44 on its way through the community of Exchange.

[1] Ninety percent of the upper portions of the watershed of West Branch Chillisquaque Creek are over sedimentary rock.

[1] The Hamilton Group primarily occurs in the central portion of the watershed of West Branch Chillisquaque Creek.

[1] The Watson-Berks-Elvira soil primarily occurs in the central portion of the watershed of West Branch Chillisquaque Creek.

The Chenango-Pope-Holly soil primarily occurs in a small area of the southeastern part of the creek's watershed.

[1] The soil is highly fertile in the upper reaches of the watershed of West Branch Chillisquaque Creek.

The developed areas are in small sections of the eastern part of the watershed of West Branch Chillisquaque Creek.

[1] The 'Chillisquaque' in West Branch Chillisquaque's name comes from a Native American word that refers to a location commonly visited by snowbirds.

[6] There are 91.15 miles (146.69 km)[7] of streams that have organic enrichment, sediment from agricultural projects, and a low level of dissolved oxygen.

Ovenbirds, black-throated green warblers, wood thrushes, blue-headed vireo and common yellowheads are the major species of birds in the watershed.