The curriculum at West Islip High School includes all academic areas, as well as art, business, music, and technology.

Beginning in Grade 7, a sequential honors program is offered in English, social studies, mathematics, science, and world languages.

Advanced Placement courses are offered in English Language and Composition, English Literature and Composition, US History, European History, Macroeconomics, Microeconomics, US Government and Politics, Calculus AB and Calculus BC, Statistics, Biology, Chemistry, Physics 1 and Physics 2, Environmental Studies, Computer Science, Studio in Art, as well as Italian and Spanish Languages.

Beginning September 2010, the high school also offers the International Baccalaureate (IB) Diploma Program.

[citation needed] The high school offers various musical & theatre groups.