[3] In his sophomore season, Tropeano had an 8–4 win–loss record with a 2.44 earned run average (ERA) and led the conference with 106 strikeouts en route to being named the America East co-Pitcher of the Year and a finalist for Pitcher of the Year by the College Baseball Hall of Fame.

He pitched in the Cape Cod Baseball League for the Cotuit Kettleers between his sophomore and junior seasons at Stony Brook.

[13] Tropeano opened the 2014 season with the Oklahoma City RedHawks of the Triple–A Pacific Coast League (PCL).

[14] Tropeano pitched to a 2.09 ERA by mid-June, but missed a month after he experienced forearm soreness in late June.

[15] After pitching to a 9–5 record with a 3.03 ERA and 120 strikeouts in 124+2⁄3 innings, the Astros promoted Tropeano to the major leagues on September 1.

He was sent down to Triple–A to begin the season but after injuries to the Angels rotation, he was called up and made 4 starts before going on the disabled list with elbow inflammation.

[22] Tropeano signed a minor league contract with the New York Yankees for the 2020 season that included a non-roster invitation to spring training.

On August 11, 2020, Tropeano was claimed off waivers by the Pittsburgh Pirates and sent to its alternate training site after Joe Musgrove was placed on the injured list.

On February 16, 2021, Tropeano signed a minor league contract worth $1.1 million with the San Francisco Giants organization that included an invitation to spring training.

[34] After splitting time between Syracuse and New York, where he gave up 1 run in 2 innings pitched, Tropeano was designated for assignment on July 30.

[41] On June 13, 2024, Tropeano signed with the Long Island Ducks of the Atlantic League of Professional Baseball.