Under the banner of WesternU Health, the university operates a variety of patient care facilities in California and Oregon.

Several nonprofit organizations are based at the WesternU Pomona campus, including the Harris Family Center for Disability and Health Policy.

Founded in 1977, the first program at WesternU was its medical school, the College of Osteopathic Medicine of the Pacific.

In 2011, the university opened an additional campus in Lebanon, Oregon, the College of Osteopathic Medicine of the Pacific - Northwest (COMP-Northwest).

[19] The following year, in 2010, the Patient Care Center opened, offering medical, dental, optometric, podiatric and pharmacy services to the community.

In 2011, Western University of Health Sciences opened a new medical school campus in Lebanon, Oregon called the College of Osteopathic Medicine of the Pacific Northwest.

In January 2015, WesternU began collaborating with colleagues in Scotland affiliated with the UK National Health Service, assisting in the development of a standardized platform for diabetes care called the Scottish Care Information Diabetes Collaboration.

[22] In October 2015, WesternU opened a Virtual Reality Learning Center to augment the teaching of anatomy across all colleges.

In November 2017, WesternU opened an Eye Care Institute in Los Angeles, which specializes in low-vision rehabilitation.

They cited a "lack of transparent communication between faculty members and Wilson, his executive leadership team and the Board of Trustees" as the reasons for their vote.

The board of trustees recognized the president's accomplishments over the past four years and both agreed that "now is an appropriate time to begin the process of identifying a new leader for WesternU."

[35] In December 2020, WesternU purchased a building in Lebanon, Oregon to house a doctor of physical therapy program.

[52][53] As a part of the interprofessional education program, students meet in small groups with a faculty facilitator and discuss non-clinical aspects of symptom presentation in complex cases, including interprofessional knowledge and awareness, financial or ethical challenges and communication barriers.

[55] Research on infections and immunology includes tuberculosis, Mad cow disease, avian flu, and Methicillin-resistant Staphylococcus aureus.

[57][58] Western University of Health Sciences provides patient care in several locations in California and Oregon.

[62] The university also offers post-graduate residency training in medicine in association with partners throughout the Western states.

Since that time, several buildings have been acquired and built, including a patient care center, a pet hospital, classrooms, and research facilities.

The Pomona campus consists of 19 major buildings spanning some seven city blocks along the main "Esplanade," which amounts to a total 22 acres (8.9 ha).

[32] The Health Education Center is a 180,000-square-foot teaching and research facility that also houses the colleges of medicine, dentistry, podiatry and optometry.

[18] The center provides primary care services such as vaccinations, spaying and neutering, microchiping, surgery, dental exams and cleanings, as well as flea, tick and heartworm control.

The Daumier is a mixed-use building located south of the pet hospital on 3.6 acres at 3rd and Linden Street.

This building was completed in June 2014, at cost of $45 million, and serves as a 173,000-square-foot facility primarily for WesternU student housing but with research and educational support space as well as a fitness center, community pool, media room, and other university offices.

In 2006, the park was named in honor of Dr. Ethan Allen, founding chairman of the school's board of trustees.

Directly south of Ethan Allan Park, the Health Professions Center houses the College of Pharmacy and contains several classrooms, research facilities, and a student commons area.

[72] The western range of campus contains the Rodney P. Wineberg Center, home to research administration and laboratories, in addition to the Pumerantz Library, and Anderson Tower (formerly known as the Chase Bank building).

[72] The building was built in 1929, and previously housed a switching station for the Pacific Telephone & Telegraph company.

[74] The Southern California Medical Museum is located in the Nursing Science Center on the WesternU campus.

[77][79] The university also operates a second campus on 50 acres in Lebanon with an official postal address at 200 Mullins Drive.