The Wetetnagami River is a tributary of the south shore of Nicobi Lake flowing in Quebec, in Canada, overlapping the administrative areas of: This river successively crosses the townships of Charrette, Adhémar, Labrie, Moquin, Effiat and Muy.

The proposed [Wetetnagami Lake Biodiversity Reserve] extends to 234.2 kilometres (145.53 mi) in the eastern part of Senneterre, Quebec, on the west side of the Gouin Reservoir.

[2] The Wetetnagami River originated in Senneterre, Quebec, at the mouth of Louison Lake (length: 4.6 kilometres (2.9 mi); maximum width: 1.8 kilometres (1.1 mi) including a bay extending to the south in the western part of the lake, altitude: 472 metres (1,549 ft)).

The confluence of the Wetetnagami River with the Nicobi Lake is located at: Formerly this territory was occupied according to the periods by the Attikameks, the Algonquins and the Cree.

The toponym "Wetetnagami River" was made official on December 5, 1968, at the Commission de toponymie du Québec, when it was created.