A second series written by Mike Carey, with Portacio returning on art duties, was started in 2006 and ended in 2008.

The story is about a team of black operative soldiers bonded with golden symbiotes, who battle against supernatural forces.

Originally intended as one of the core Image Comics launch titles in 1992, the series was put on hiatus until 1994 due to the death of Portacio's sister.

After re-solicitation by Image (through Jim Lee's Wildstorm imprint), the original series ran for 43 issues, from 1994–1998.

Wetworks reappeared as one of the one-shots in Wildstorm: Armageddon, but it was not one of the series restarted following the World's End events.

Mother One explained to Team 7 they were double-crossed by Craven and I/O and asked them to accompany her to her boss, industrialist Armand Waering.

Several members of the squad died during a major mission some time later, including Dozer and Claymore, and Wetworks broke up.

Recently Dane has reactivated the team to deal with breaks in reality caused by another superteam, which have been turned into portals for forces from another dimension.

Dane refuses his proposal since he no longer believes in a simple solution, and prefers tasking the Wetworks of defending humanity from the vampires.

Switching tactics the Pilgrim proceeded by kidnapping family members of the team, using them to blackmail Rip into surrendering themselves.

She began to reflect their attacks backwards, but was stabbed by the younger Rip Hunter, which distracted her and led the team to disintegrating her into ash.