The series takes its title from the 1980 song of the same name by American rock band The Romantics; it was written by the group's members Wally Palmar, Mike Skill, Rich Cole, and Jimmy Marinos.

The first season's opening sequence features intercut scenes (as from home movies) of two girls portraying younger versions of Holly and Val, with shots of Bynes and Garth sticking their tongues out at the camera, mixed with footage excerpted from the first four episodes.

The opening title sequence for the rest of the series features the show's cast in front of digitally inserted scenes of New York at night.

Due to music costs, and rights, DVD and streaming releases replace the theme song of Lillix's cover.

Remarking upon it when the series was added to HBO Max in January 2021 with the replacement music, TVLine called it "royalty-free garbage that not even Shazam can identify.

In Italy, the series aired under the name Le cose che amo di te (The things I Love about you) on Rai 2 from July 7, 2006 until August 2, 2008.

Reruns of the series moved to The CW (which replaced The WB) on September 18, 2006, airing for a full hour at 3:00PM on weekdays alongside Reba.