He played all or part of sixteen seasons in Major League Baseball for the Detroit Tigers (1929–33), Chicago White Sox (1933–36), Cleveland Indians (1937), Brooklyn Dodgers (1939–44), and Philadelphia Phillies (1945).

While injuries sidetracked much of Wyatt's early career,[1] he is most famous for his performance in 1941, when his team (the Dodgers) won the National League pennant.

In 1932, Wyatt managed his first full season, appearing in 43 games, including 22 starts, with a 9–13 record and a 5.03 ERA.

In the midst of an MVP season in the American Association,[1] during which he won 23 games for the Milwaukee Brewers, he was purchased by the Brooklyn Dodgers.

"[1] In a 16-season career, Wyatt posted a 106–95 record with 872 strikeouts and a 3.79 ERA in 1761 innings pitched, including 17 shutouts and 97 complete games.

After retiring from the mound, Wyatt was a successful minor-league manager (his 1954 Atlanta Crackers won the Double-A Southern Association championship and Dixie Series), then spent over a decade as a pitching coach in the majors with the Philadelphia Phillies (1955–57) and the Milwaukee / Atlanta Braves (1958–67), notably serving on the pennant-winning 1958 Milwaukee Braves and as the first pitching coach for the relocated Atlanta Braves of 1966.