White Clay Creek is an 18.5-mile-long (29.8 km)[2] tributary of the Christina River in southern Pennsylvania and northern Delaware in the United States.

The southern portion of the stream, near Newark is in the Atlantic Coastal Plain, a relatively flat area that is dotted with large tidal wetlands.

Further south, after the confluence of Egypt Run, the creek begins to turn and meander in a narrow gorge, passing through Landenberg, formerly a mill town and the junction of the Pomeroy & Newark with the Wilmington and Western Railroad.

Turning south, it cuts sharply through the hills near Chesterville and meets the West Branch to form the main stem.

Just after passing the island, White Clay Creek enters the Christina approximately 5 miles (8 km) southwest of Wilmington at Churchman's Marsh.

In 2000, the United States Congress designated 190 miles (310 km) of White Clay Creek and its tributaries as part of the National Wild and Scenic River program.