Whitmire is a town in Newberry County, South Carolina, United States, along the Enoree River.

The earliest settler in what is now Whitmire was John Duncan, who built a house along the creek that now bears his name.

The George Frederick Whitmire family arrived prior to the 1790s (1790 Census) and established a tavern and post office.

[5] In 1902, William Coleman and several associates established a large textile factory known as the Glenn-Lowery Mill, which included 900 looms and 33,000 spindles.

[6] The town is concentrated around the intersection of U.S. Route 176 and South Carolina Highway 72, northwest of Columbia and southeast of Spartanburg.

According to the United States Census Bureau, the town has a total area of 1.3 square miles (3.3 km2), all land.

Whitmire earned the title "Pearl of the Piedmont" for its status as a successful textile town, but by the early 2010s the last mill was closed.