Based on the 1988 film of the same title, it is one of the earliest games designed by Shinji Mikami.

Roger is summoned by Marvin Acme to his factory to take his deed and get his will from Jessica Rabbit to save Toontown from the greedy Judge Doom, who is going to use a machine filled with dip to obliterate Toontown.

Through his investigation Roger faces Stupid, Sleazy, Greasy, Psycho, and Smart Ass (censored as Smarty in the game) and finally makes it to Doom's mansion.

They make it past the complex and confront Doom, defeating him and destroying the machine.

Scattered in the game are traps and ambushing weasels waiting to hurt Roger.