[3] Contributions are monitored by a group of admins, but the bulk of peer review, editorial curation, and maintenance is the responsibility of the user community.

WikiPathways is originally built using MediaWiki software,[4] a custom graphical pathway editing tool (PathVisio[5]) and integrated BridgeDb[6] databases covering major gene, protein, and metabolite systems.

WikiPathways was founded in 2008 by Thomas Kelder, Alex Pico, Martijn Van Iersel, Kristina Hanspers, Bruce Conklin and Chris Evelo.

In addition to various primary data formats (e.g. GPML, BioPAX, Reactome,[10] KEGG, and RDF[11]), WikiPathways supports a variety of ways to integrate and interact with pathway content.

[13] WikiPathways content is used to annotate and cross-link Wikipedia articles covering various genes, proteins, metabolites and pathways.