While at South Carolina, in April 2015, Crowe tore the ulnar collateral ligament in his right throwing elbow and underwent Tommy John surgery performed by Dr. James Andrews.

[3] Crowe made his return to pitching on June 1, 2016, starting the home opener for the Lexington County Blowfish and showing off a sharp slider and a fastball that reached 95 miles per hour (153 km/h).

[4] The Indians again selected him in the 2016 MLB draft, using their 21st-round pick on him, but Crowe again did not sign, returning to South Carolina as a redshirt junior.

[8] Crowe made his professional debut with the rookie–level Gulf Coast League Nationals, and after giving up two earned runs in 3+2⁄3 innings, was promoted to the Auburn Doubledays, where he finished the season, posting a 2.61 ERA with a 1.02 WHIP in seven games started.

[9] Crowe opened his season with the High–A Potomac Nationals in 2018 by winning eleven straight decisions,[10][11] earning a berth in the Carolina League All-Star Game.

[13] In 2019, Crowe was invited to participate in his first major league spring training as a non-roster invitee,[14] giving him the opportunity to work with veteran Nationals pitchers Patrick Corbin, Max Scherzer, and Stephen Strasburg, something he described to The Washington Post as "like getting a PhD in pitching".

On September 20, 2022, Crowe delivered a pitch that Aaron Judge hit for his 60th home run of the season, tying Babe Ruth for the second-most in New York Yankees history.