They have produced national commercials for clients such as Esurance,[1] Chiclets, Target, Nike, Honda, Kraft, The Wall Street Journal, and Lamisil (featuring Digger the Dermatophyte).

[3] In 1994, John Hays, Phil Robinson, and Jeff Fino founded Wild Brain in the Castro District of San Francisco, California.

In 1996, Wild Brain moved to a 17,000 square foot warehouse at the corner of 18th St. and York St. in the Mission District spearheading the growth of what came to be known in San Francisco as Multimedia Gulch.

In 2007, former founder Jeff Fino left to start Nuvana, an educational web-based company with former Colossal Pictures producer, Joe Kwong.

Around this time, John Hays left Wildbrain to work on indie features La Mission and Howl, which opened the 2010 Sundance Film Festival.

The company expanded its animation studios to Sherman Oaks in March, then closed its San Francisco office in June.

That same year, Phil Robinson and Amy Capen, executive producer of Wildbrain's San Francisco studio, started an independent company called Special Agent Productions.