Wiley Thompson (September 23, 1781 – December 28, 1835) was a United States representative from Georgia.

He served in the Georgia Senate from 1817 to 1819 and was appointed Major General of the Fourth Division of the Georgia Militia[1] in November 1817, a position in which he served until his resignation in November 1824.

[2] After his congressional service, Thompson served as a delegate to the State constitutional convention in 1833.

This episode of his life was artistically described by Thomas Mayne Reid in the 1858 novel Osceola.

Thompson was subsequently killed by a band of Seminoles led by Osceola at Fort King, Florida, on December 28, 1835, and was buried on his estate in Elberton.