Wilhelm Uhthoff (31 July 1853 – 21 March 1927) was a German ophthalmologist born in Klein-Warin.

Uhthoff specialized in the study of ophthalmological disorders that were related to the central nervous system.

In 1890 he described a condition of temporary vision loss linked to physical exercise, and associated with optic neuritis.

In 1915 he published a treatise titled Augensymptome bei Grosshirntumoren in which gave an early description of a neuro-ophthalmic disorder that was to become known as Foster Kennedy syndrome.

[1] However, the disease was to be named after Robert Foster Kennedy (1884–1952), who provided a more comprehensive (and earlier) account of the disorder.