She was the fourth child of eight born to King Frederick William II of Prussia and Queen Frederica Louisa.

The marriage was arranged as a part of an alliance between the House of Orange and Prussia, but it was also, in fact, a love match and became a happy one.

[1] In 1806, Wilhelmine was again forced to flee from the French army, and settled under difficult economic circumstances in Poland.

Beginning in 1820, her health worsened, and after 1829, she was rarely seen in public, though she continued her trips to Berlin and visiting relatives.

[1] She was a student of Friedrich Bury, financed an Italian study trip for Bonaventura Genelli, and supported the renovation of the royal museum.