Born at Antwerp about the year 1647, he was trained as a jeweller, but as an amateur practised in miniature, enamel, and oil-colours.
Having painted some altar-pieces at Antwerp, his business called him to Dunkirk, where he painted a picture, for the chapel of the English nuns, who were so pleased with it, that they persuaded De Keyser to go to England, and gave him letters of recommendation to Lord Melfort, then in favour with James II.
The enthusiastic painter could not resist the proposal; he embarked on board an English vessel, and, unknown to his wife or family, sailed for England.
He was introduced to the king, who promised to countenance him, and several persons of rank, who had known him at Antwerp, encouraged him in his new vocation.
Within half a year the bubble burst; the Revolution happened, De Keyser's friends could no longer be his protectors, his business decreased, and the pursuit of the philosopher's stone, to which he had recourse in his despair, completed his ruin.