They had children William Angie III, Bryant Wesley and Shelby Lee.
William was also a member of the honorary fraternities Tau Kappa Alpha and Theta Phi.
William Angie Smith entered the Texas Annual Conference of the Methodist Episcopal Church, South in 1921 and was appointed the pastor of the Kerrville, Texas M.E., S. Church, serving 1920–21.
He was elected by the M.E., S. College of Bishops as a Fraternal Messenger of his denomination to the Methodist Protestant General Convention in 1936.
Dr. William Angie Smith was elected to the episcopacy of The Methodist Church, 13 June 1944, by the South Central Jurisdictional Conference meeting at Tulsa, Oklahoma.
Then he was made President of the General Commission on the structure of Methodism overseas, specifically charged with conferring with missionaries, local clergy, and national leaders in Europe, Asia, Taiwan and Japan.
William Angie Smith was awarded the honorary degree Doctor of Divinity in 1927 by McMurry College.
He has also served as President of the Board of Trustees of Oklahoma City University, which named a chapel for him.